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The meaning of LOSE is to miss from one's possession or from a customary or supposed place. How to use lose in a sentence.

lose verb (NO LONGER POSSESS) [ T ] to no longer have something, because it has been taken away from you, either by accident or purposely:

2. to fail to keep or maintain: to lose one's balance. 3. to suffer the loss or deprivation of: to lose a parent.

lose (lo̅o̅z), v., lost, los•ing. v.t. to come to be without (something in one's possession or care), through accident, theft, etc., so that there is little or no prospect of recovery: I'm sure I've merely misplaced …

If you lose something, you do not know where it is, for example because you have forgotten where you put it. I lost my keys. [VERB noun] I had to go back for my checkup; they'd lost my X-rays. [VERB noun]

LOSE definition: to come to be without (something in one's possession or care), through accident, theft, etc., so that there is little or no prospect of recovery. See examples of lose used in a sentence.